Effect of pomegranate juice (Punica Granatum) on behavioral patterns of intake in rats with induced diabetes

Abstract

Evidence on the alternative treatment of diabetes mellitus is now growing through functional foods such as pomegranate juice. Most studies focus on the physiological effect of juice when administered by gavage to diabetic rats. The objective was to evaluate the effect of free access to pomegranate juice exposure on the consumption of liquids, food intake, and body weight in diabetic rats. Two groups of six healthy rats and six hyperglycemic rats, induced with 60 mg/kg of intraperitoneal streptozotocin, were exposed to pomegranate juice, water, and food for 21 days. The results showed significant differences (p < 0.05) in fluid consumption and body weight in both groups. There were no significant differences in food intake (p > 0.05). The free access exposure to pomegranate juice showed its acceptance and generated behavioral differences in the intake.

https://doi.org/10.15174/au.2019.1997
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References

Aboonabi, A., Rahmat, A., & Othman, F. (2014). Antioxidant effect of pomegranate against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. Toxicology Reports, 1, 915–922. doi:10.1016/j.toxrep.2014.10.022

Al-Olayan, E. M., El-Khadragy, M. F., Metwally, D. M., & Abdel Moneim, A. E. (2014). Protective effects of pomegranate (Punica granatum) juice on testes against carbon tetrachloride intoxication in rats. BMC Complementary and Alternative Medicine, 14(1), 1-9. doi:10.1186/1472-6882-14-164

Akbarzadeh, A., Norouzian, D., Mehrabi, M. R., Jamshidi, S., Farhangi, A., Verdi, A. A., … Rad, B. L. (2007). Induction of diabetes by Streptozotocin in rats. Indian Journal of Clinical Biochemistry, 22(2), 60–64. doi:10.1007/BF02913315

Bagri, P., Ali, M., Aeri, V., Bhowmik, M., & Sultana, S. (2009). Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food and Chemical Toxicology, 47(1), 50–54. doi:10.1016/j.fct.2008.09.058

Banihani, S. A., Makahleh, S. M., El-Akawi, Z., Al-Fashtaki, R. A., Khabour, O. F., Gharibeh, M. Y., … Al-Khasieb, N. J. (2014). Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients. Nutrition Research, 34(10), 862–867. doi:10.1016/j.nutres.2014.08.003

Bhaskar, A., & Kumar, A. (2012). Antihyperglycemic, antioxidant and hypolipidemic effect of Punica granatum L flower extract in streptozotocin induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine, 2(3), 1764–1769. doi:10.1016/S2221-1691(12)60491-2

Bolsinger, J., Pronczuk, A., Sambanthamurthi, R., & Hayes, K. C. (2014). Anti-diabetic effects of palm fruit juice in the Nile rat (Arvicanthis niloticus). Journal of Nutritional Science, 3(5). doi:10.1017/jns.2014.3

Booth, D. A. (1972). Some characteristics of feeding during streptozotocin-induced diabetes in the rat. Journal of Comparative and Physiological Psychology, 80(2), 238–249. doi:10.1037/h0032968

De Castro, J. M., & Balagura, S. (1975). Meal patterning in the streptozotocin-diabetic rat. Physiology & Behavior, 15(3), 259–263. doi:10.1016/0031-9384(75)90091-8

Farias, M., Wohlenberg, L. K., Gonçalves, T. K., Schaffer, D. K., Hilger, R. D., Braccini Neto, C., … Funchal, C. D. (2015). Effect of grape juice on some biochemical and oxidative stress parameters in serum and liver enzymes of pregnant and lactating rats. Issues in Biological Sciences and Pharmaceutical Research, 3(4), 37–46. doi:10.15739/ibspr.011

Flores, C. J. (2011). De los modelos animales a la práctica psicológica: el surgimiento de algunas técnicas aplicadas a problemas de salud. Suma Psicológica, 18(1), 115–123. Recuperado de http://www.redalyc.org/pdf/1342/134218661011.pdf

Granneman, J., & Stricker, E. (1984). Food intake and gastric emptying in rats with streptozotocin-induced diabetes. American Journal of Physiology, 247(6), 1054–1061. Recuperado de http://citeseerx.ist.psu.edu/viewdoc/download;jsessionid=A43D27A77C4B637A8AF872FAA3364393?doi=10.1.1.913.2255&rep=rep1&type=pdf

Hallfrisch, J., Lev Lazar, F., & Reiser, S. (1979). Effect of feeding sucrose or starch to rats made diabetic with streptozotocin. The Journal of nutrition, 109(11), 1909–1915. Recuperado de http://jn.nutrition.org/content/109/11/1909.extract

Hernandez, L., & Briese, E. (1972). Analysis of diabetic hyperphagia and polydipsia. Physiology & Behavior, 9(5), 741–746. doi:10.1016/0031-9384(72)90044-3

Lee, C.-J., Chen, L.-G., Liang, W.-L., & Wang, C.-C. (2010). Anti-inflammatory effects of Punica granatum Linne in vitro and in vivo. Food Chemistry, 118(2), 315–322. doi:10.1016/j.foodchem.2009.04.123

Miguel, M., Neves, M., & Antunes, M. (2010). Pomegranate (Punica granatum L.): A medicinal plant with myriad biological properties - A short review. Journal of Medicinal Plants Research, 4(25), 2836–2847. Recuperado de http://www.academicjournals.org/article/article1380714856_Miguel%20et%20al.pdf

Mirmiran, P., Bahadoran, Z., & Azizi, F. (2014). Functional foods-based diet as a novel dietary approach for management of type 2 diabetes and its complications: A review. World Journal of Diabetes, 5(3), 267-281. doi:10.4239/wjd.v5.i3.267

Miyata, M., Takano, H., Q.Guo, L., Nagata, K., & Yamazoe, Y. (2004). Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity. Carcinogenesis, 25(2), 203–209. doi:10.1093/carcin/bgg194

Osman, H., Eshak, M., El-Sherbiny, E., & Bayoumi, M. (2012). Biochemical and genetical evaluation of pomegranate impact on diabetes mellitus induced by alloxan in female rats. Life Science Journal, 9(3), 1543–1553. Recuperdo de

http://www.lifesciencesite.com/lsj/life0903/225_10224life0903_1543_1553.pdf

Pathak, M. (2014). Diabetes mellitus type 2 and functional foods of plant origin. Recent Patents on Biotechnology, 8(2), 160–164. doi:10.2174/1872208309666140904120633

Prasetyastuti, Anthony, M. W. P., Rahman, N. A., Ngadikun, & Sunarti. (2014). Hypoglycemic and antioxidative effects of pomegranate (Punica granatum L.) juice in streptozotocin induced diabetic rats. Pakistan Journal of Nutrition, 13(10), 567–572. doi:10.3923/pjn.2014.567.572

Ribes, E. (2011). ¿Por qué es necesario estudiar el comportamiento animal? Suma Psicológica, 18(1), 9–15. Recuperado de http://www.scielo.org.co/pdf/sumps/v18n1/v18n1a02.pdf

Richter, C. P. (1941). Behavior and endocrine regulators of the internal environment. Endocrinology, 28(2), 193–195. doi:10.1210/endo-28-2-193

Richter, C. P., & Schmidt, E. C. H. (1941). Increased fat and decreased carbohydrate appetite of pancreatectomized rats. Endocrinology, 28(2), 179–192. doi:10.1210/endo-28-2-179

Richter, C. (1943). Total self-regulatory functions in animals and human beings. Harvey Lecture Series, 38, 63–103. Recuperado de https://www.ssib.org/web/classics/Richter%20Self%20regulatory%20functions%20Harvey%20Lect%201943.pdf

Smith, J. C., & Gannon, K. S. (1991). Ingestion patterns of food, water, saccharin and sucrose in streptozotocin-induced diabetic rats. Physiology & Behavior, 49(1), 189–199. doi:10.1016/0031-9384(91)90253-K

Sreekumar, S., Sithul, H., Muraleedharan, P., Azeez, J. M., & Sreeharshan, S. (2014). Pomegranate Fruit as a rich source of biologically active compounds. BioMed Research International, 2014, 1–12. doi:10.1155/2014/686921

Taheri Rouhi, S. Z., Sarker, M. M. R., Rahmat, A., Alkahtani, S. A., & Othman, F. (2017). The effect of pomegranate fresh juice versus pomegranate seed powder on metabolic indices, lipid profile, inflammatory biomarkers, and the histopathology of pancreatic islets of Langerhans in streptozotocin-nicotinamide induced type 2 diabetic Sprague–Dawley rats. BMC Complementary and Alternative Medicine, 17(1). doi:10.1186/s12906-017-1667-6

Tsang, C., Smail, N. F., Almoosawi, S., Davidson, I., & Al-Dujaili, E. A. S. (2012). Intake of polyphenol-rich pomegranate pure juice influences urinary glucocorticoids, blood pressure and homeostasis model assessment of insulin resistance in human volunteers. Journal of Nutritional Science, 1. doi:10.1017/jns.2012.10

Viuda-Martos, M., Fernández-López, J., & Pérez-Álvarez, J. A. (2010). Pomegranate and its many functional components as related to human health: A review. Comprehensive Reviews in Food Science and Food Safety, 9(6), 635–654. doi:10.1111/j.1541-4337.2010.00131.x

Wang, R., Ding, Y., Liu, R., Xiang, L., & Du, L. (2010). Pomegranate: constituents, bioactivities, and pharmacokinetics. Fruit, Vegetable and Cereal Science and Biotechnology, 4(2), 77–87. Recuperado de http://www.globalsciencebooks.info/Online/GSBOnline/images/2010/FVCSB_4(SI2)/FVCSB_4(SI2)77-87o.pdf